MODULATION OF RAB7A-MEDIATED GROWTH FACTOR RECEPTOR TRAFFICKING INHIBITS ISLET BETA CELL APOPTOSIS AND AUTOPHAGY UNDER CONDITIONS OF METABOLIC STRESS

Abstract Regenerative medicine approaches to enhancing beta cell growth and survival represent potential treatments for diabetes.It is known that growth factors such as insulin, IGF-1 and HGF support beta cell growth and survival, but in people with type 2 diabetes the destructive effects of metabolic stress predominate and beta cell death or dysfu

Aim: Review of our experience and to develop an algorithm for salvage procedures in the management of hypospadias cripples and treatment of urethral strictures following hypospadias repair.Methods: This is a retrospective review of hypospadias surgeries over a 41-month period.Out of a total 168 surgeries, 20 were salvage/re-operative repairs.In thr

Ling Zhao,1 Wei Wang,1 Jiwen Zhong,1 YaYun Li,1 YanZi Cheng,1 Zhenjiao Su,1 Wei Zheng,1 Xiang-Dong Guan2 1Department of Critical Care Medicine, Zhuhai People’s Hospital, Zhuhai, Guangdong, 2Department of Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China Purp

IntroductionPrior research has found that experiences with violence in the U.S.differ across individual demographic characteristics, including race, gender, and sexual orientation.However, peer reviewed studies have yet to examine the relationship between the intersections of race, gender, and sexual orientation, victimization risk, and characteris

iPod Wire The Management of marketing mix in agro-industry business of pineapple chips need to increase the volume of sales and customer loyalty.This research aims to (1) analyze the variable/ attribute lever in the management of the marketing mix of pineapple chips, and (2) formulating marketing strategy of pineapple chips.This research used surve